Soft- and entrepreneurial skills are the two areas that employers have agreed that make the difference in choice when hiring college graduates; this is especially so in BioTechnology, Information Technology, Computer Science and other high-tech fields. This Call for Participation is for a National Science Foundation supported Faculty Development Seminar that brings Virtual Enterprise to the BioTech and Information Technology disciplines. Its objective is to bring our students in line with industry’s demand for soft-skills while giving them the sense that becoming a tech-entrepreneur is not something that’s out of their reach, especially in the current economic climate.