The 2014 American Association for the Advancement of Science (AAAS) Annual Meeting in Chicago will focus on finding sustainable solutions through inclusive, international, and interdisciplinary efforts that are most useful to society and enhance economic growth. The 2014 program includes more than 150 sessions on topics including global public health security, dark matter discoveries, climate change at the poles, therapeutic video games, advances in STEM education, and the applications and impacts of “big data.”