In the NSF funded Center on Advanced Self-Powered Systems of integrated sensors and technologies (ASSIST) we are hoping to change the world of health care by building wearable health monitoring devices that are battery-free. These devices are powered by body heat and body motion and enable continuous health monitoring without any user intervention. Coupled with critical health and environmental sensors these always-on devices can enable long term monitoring and help in establishing personal health trends which are simply nonexistent today. These technologies can help our society move away from managing illness towards managing wellness. The focus of the talk will be on self-powered wearable, wireless health monitoring systems for addressing the grand challenges of healthcare. Learn how power is being harvested from the human body in the form of heat and motion and utilized very effectively using low power electronics. Our work will be discussed on building medically validated low-power health sensors (EKG, hydration and biomarkers) and personal environmental exposures such as ozone which are related to Asthma.