Drug Discovery 1: How Does the New SARS-CoV-2 Protease Inhibitor Block Protease Activity?

This video, provided by Digital World Biology, is from a series of tutorial videos for iCn3D, a web-based three-dimensional visualization and structural analysis platform for molecular structures. During this video, presenter Sandra Porter offers step-by-step instructions on how to view and analyze the interaction between a protease drug and SARS-CoV-2. The video guides viewers on how to:

• Select the inhibitor, the inhibitor binding site, and amino acids in the active site.
• Identify amino acids in the inhibitor binding site.
• Annotate the inhibitor binding site and the two amino acids that form the catalytic dyad.
• Identify a covalent bond to the inhibitor.
• View the binding pocket for the inhibitor.
• Identify a hydrogen bond to the inhibitor and determine which amino acid forms this bond.

This video runs 14:02 minutes in length. Additional videos in the series are available to view separately.